2026-08-05T11:38:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/110272025-04-30T13:12:30Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959col_20.500.12105_16962col_20.500.12105_16968col_20.500.12105_16970col_20.500.12105_16974col_20.500.12105_16983col_20.500.12105_16990col_20.500.12105_19617
Repisalud
author
García-Pérez, Javier
author
Fernandez de Larrea-Baz, Nerea
author
Lope Carvajal, Virginia
author
Molina, Antonio J.
author
O'Callaghan-Gordo, Cristina
author
Alonso, María Henar
author
Rodríguez-Suárez, Marta María
author
Mirón-Pozo, Benito
author
Alguacil, Juan
author
Gómez-Acebo, Inés
author
Ascunce, Nieves
author
Vanaclocha-Espi, Mercedes
author
Amiano, Pilar
author
Chirlaque, María-Dolores
author
Simó, Vicente
author
Jimenez-Moleon, Jose J.
author
Tardón, Adonina
author
Moreno, Victor
author
Castaño-Vinyals, Gemma
author
Martín, Vicente
author
Aragones, Nuria
author
Perez-Gomez, Beatriz
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
funder
Asociación Española Contra el Cáncer
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Marqués de Valdecilla
funder
Fundación Caja de Ahorros de Asturias
funder
Basque Government (España)
funder
Generalitat Valenciana (España)
funder
Regional Government of Andalusia (España)
funder
Government of Catalonia (España)
funder
Fundación La Caixa
funder
Unión Europea. Comisión Europea
funder
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
2020-09-16T09:55:40Z
2020-09-16T09:55:40Z
2020-08-19
Environ Int. 2020 Aug 19;144:106055.
10.1016/j.envint.2020.106055
1873-6750
0160-4120
Environment international
32827807
http://hdl.handle.net/20.500.12105/11027
Background: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze the association between colorectal cancer risk and residential proximity to industries, according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances, and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Methods: MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched by sex, age, and region of residence. Distances were computed from subjects' residences to each of the 134 industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for matching variables and other confounders. Results: Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances analyzed, from 1 km (2.03; 1.44-2.87) to 3 km (1.26; 1.00-1.59). In general, industries releasing pollutants to air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR; 95%CI) was found near (≤3 km) production of metals (2.66; 1.77-4.00), surface treatment of metals (1.48; 1.08-2.02), glass and mineral fibers (2.06; 1.39-3.07), organic chemical industry (4.80; 3.20-7.20), inorganic chemical industry (6.74; 4.38-10.36), food/beverage sector (3.34; 2.38-4.68), and surface treatment using organic solvents (6.16; 4.06-9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (≤3 km) industries releasing nonylphenol (9.19; 5.91-14.28), antimony (5.30; 3.45-8.15), naphthalene (3.11; 2.16-4.49), organotin compounds (2.64; 1.76-3.98), manganese (2.53; 1.63-3.93), dichloromethane (2.52; 1.74-3.66), and vanadium (2.49; 1.59-3.91). Conclusions: Our results support the hypothesis that residing in the proximity of industries may be a risk factor for colorectal cancer.
eng
Colorectal cancer
Industrial pollution
MCC-Spain
Case-control study
Residential proximit
Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
research article
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SUPLEMENTARYDATAResidentialProximityToIndustrial_2020.pdf
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ResidentialProximityToIndustrial_2020.pdf.txt
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