2026-05-01T10:37:56Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/109862025-03-21T10:11:48Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
García-Romero, N
author
Palacín-Aliana, I
author
Madurga, R
author
Carrión-Navarro, J
author
Esteban-Rubio, Susana
author
Jiménez, B
author
Collazo, A
author
Pérez-Rodríguez, F
author
Ortiz de Mendivil, A
author
Fernández-Carballal, C
author
García-Duque, S
author
Diamantopoulos-Fernández, J
author
Belda-Iniesta, Cristobal
author
Prat-Acín, R
author
Calvo, E
author
Ayuso-Sacido, Angel
author
Sánchez-Gómez, Pilar
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Economía y Competitividad (España)
2020-09-07T19:28:27Z
2020-09-07T19:28:27Z
2020-06-22
BMC Med . 2020 Jun 22;18(1):142.
10.1186/s12916-020-01610-0
1741-7015
1741-7015
BMC medicine
32564774
http://hdl.handle.net/20.500.12105/10986
Glioblastoma (GBM) is one of the most aggressive and vascularized brain tumors in adults, with a median survival of 20.9 months. In newly diagnosed and recurrent GBM, bevacizumab demonstrated an increase in progression-free survival, but not in overall survival. We conducted an in silico analysis of VEGF expression, in a cohort of 1082 glioma patients. Then, to determine whether appropriate bevacizumab dose adjustment could increase the anti-angiogenic response, we used in vitro and in vivo GBM models. Additionally, we analyzed VEGFA expression in tissue, serum, and plasma in a cohort of GBM patients before and during bevacizumab treatment. We identified that 20% of primary GBM did not express VEGFA suggesting that these patients would probably not respond to bevacizumab therapy as we proved in vitro and in vivo. We found that a specific dose of bevacizumab calculated based on VEGFA expression levels increases the response to treatment in cell culture and serum samples from mice bearing GBM tumors. Additionally, in a cohort of GBM patients, we observed a correlation of VEGFA levels in serum, but not in plasma, with bevacizumab treatment performance. Our data suggest that bevacizumab dose adjustment could improve clinical outcomes in Glioblastoma treatment.
eng
Bevacizumab dose adjustment to improve clinical outcomes of glioblastoma.
research article
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URL
https://repisalud.isciii.es/bitstreams/fccbaf37-d4fc-45fb-9ed5-c31707ea57a7/download
File
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application/pdf
BevacizumabDoseAdjustmentTo_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/1b58c2b9-f860-4b20-8b8e-255f5f421cdb/download
File
MD5
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text/plain
BevacizumabDoseAdjustmentTo_2020.pdf.txt