2026-05-20T23:01:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/109822025-04-07T18:52:38Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
García-Romero, Noemí
author
Palacín-Aliana, Irina
author
Esteban-Rubio, Susana
author
Madurga, Rodrigo
author
Rius-Rocabert, Sergio
author
Carrión-Navarro, Josefa
author
Presa, Jesús
author
Cuadrado-Castano, Sara
author
Sánchez-Gómez, Pilar
author
García-Sastre, Adolfo
author
Nistal-Villan, Estanislao
author
Ayuso-Sacido, Angel
funder
National Institutes of Health (Estados Unidos)
funder
Banco Santander
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Ministerio de Economía y Competitividad (España)
funder
CEU San Pablo University
2020-09-04T20:14:00Z
2020-09-04T20:14:00Z
2020-06-05
Cells. 2020 Jun 5;9(6):1405.
10.3390/cells9061405
2073-4409
Cells
32516884
http://hdl.handle.net/20.500.12105/10982
Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor in adults with a median overall survival of 15 months. Tumor recurrence and poor prognosis are related to cancer stem cells (CSCs), which drive resistance to therapies. A common characteristic in GBM is CDKN2A gene loss, located close to the cluster of type I IFN genes at Ch9p21. Newcastle disease virus (NDV) is an avian paramyxovirus with oncolytic and immunostimulatory properties that has been proposed for the treatment of GBM. We have analyzed the CDKN2A-IFN I gene cluster in 1018 glioma tumors and evaluated the NDV oncolytic effect in six GBM CSCs ex vivo and in a mouse model. Our results indicate that more than 50% of GBM patients have some IFN deletion. Moreover, GBM susceptibility to NDV is dependent on the loss of the type I IFN. Infection of GBM with an NDV-expressing influenza virus NS1 protein can overcome the resistance to oncolysis by NDV of type I-competent cells. These results highlight the potential of using NDV vectors in antitumor therapies.
eng
Newcastle Disease Virus (NDV) Oncolytic Activity in Human Glioma Tumors Is Dependent on CDKN2A-Type I IFN Gene Cluster Codeletion
research article
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URL
https://repisalud.isciii.es/bitstreams/8675b64a-e0fa-495b-94a3-0c621b2f408b/download
File
MD5
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application/pdf
NewcastleDiseaseVirusNDV_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/bacc0be9-c3ed-45c0-9df2-927780e131fa/download
File
MD5
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text/plain
NewcastleDiseaseVirusNDV_2020.pdf.txt