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oai:repisalud.isciii.es:20.500.12105/109122024-11-30T01:04:49Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Toda, Haruka author Diaz-Varela, Miriam author Segui-Barber, Joan author Roobsoong, Wanlapa author Baro, Barbara author Garcia-Silva, Susana author Galiano, Alicia author Gualdrón-López, Melisa author Almeida, Anne C G author Brito, Marcelo A M author de Melo, Gisely Cardoso author Aparici-Herraiz, Iris author Castro-Cavadía, Carlos author Monteiro, Wuelton Marcelo author Borràs, Eva author Sabidó, Eduard author Almeida, Igor C author Chojnacki, Jakub author Martinez-Picado, Javier author Calvo, Maria author Armengol, Pilar author Carmona-Fonseca, Jaime author Yasnot, Maria Fernanda author Lauzurica, Ricardo author Marcilla, Antonio author Galinski, Mary R author Lacerda, Marcus V G author Sattabongkot, Jetsumon author Fernandez-Becerra, Carmen author Del Portillo, Hernando A author Peinado Selgas, Hector author 2020 Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen. Nat Commun. 2020 ;11(1):2761. 10.1038/s41467-020-16337-y 2041-1723 Nature communications 32487994 http://hdl.handle.net/20.500.12105/10912 Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence.