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oai:repisalud.isciii.es:20.500.12105/109032025-05-08T18:10:16Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16961col_20.500.12105_16978col_20.500.12105_16984

00925njm 22002777a 4500 dc Fernandez de Larrea-Baz, Nerea author Perez-Gomez, Beatriz author Guerrero-Zotano, Ángel author Casas, Ana María author Bermejo, Begoña author Baena-Cañada, José Manuel author Antolín, Silvia author Sánchez-Rovira, Pedro author Ramos-Vázquez, Manuel author García-Sáenz, José Ángel author Antón, Antonio author Muñoz, Montserrat author de Juan, Ana author Jara, Carlos author Chacón, José Ignacio author Arcusa, Angels author Gil-Gil, Miguel author Adrover, Encarna author Oltra, Amparo author Brunet, Joan author González, Sonia author Bezares, Susana author Lope Carvajal, Virginia author Martín, Miguel author Pollan-Santamaria, Marina author 2020-05-08 This study evaluates the impact of breast cancer (BC) in health related quality of life (HRQL) and in psychological distress (PD) during the initial phases of the disease and looks for contributing factors. A multicentric case-control study, EpiGEICAM, was carried out. Incident BC cases and age- and residence- matched controls were included. Clinical, epidemiological, HRQL (SF-36) and PD information (GHQ-28) was collected. We used multivariable logistic regression models to estimate OR of low HRQL and of PD in cases compared to controls, and to identify factors associated with low HRQL and with PD. Among 896 BC cases and 890 control women, cases had poorer scores than both, the reference population and the control group, in all SF-36 scales. BC women with lower education, younger, active workers, never smokers, those with comorbidities, in stage IV and with surgical treatment had lower physical HRQL; factors associated with low mental HRQL were dissatisfaction with social support, being current smoker and having children. Cases had a fivefold increased odds of PD compared to controls. Managing comorbidities and trying to promote social support, especially in younger and less educated women, could improve well-being of BC patients. Sci Rep. 2020; 10: 7741. 10.1038/s41598-020-63637-w 2045-2322 Scientific reports 32385335 http://hdl.handle.net/20.500.12105/10903 Quality of life Epidemiology Breast cancer Cancer epidemiology Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study