2026-06-14T03:38:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/108782025-05-05T17:22:04Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Perez-Garcia, Felipe
author
Soria, Susana
author
Jorge-Monjas, Pablo
author
Gómez-Sánchez, Esther
author
Heredia-Rodríguez, María
author
Gómez-Pesquera, Estefanía
author
Martínez-Paz, Pedro
author
Tamayo, Eduardo
author
Resino, Salvador
author
Fernandez-Rodriguez, Amanda
author
Jimenez-Sousa, Maria Angeles
funder
Instituto de Salud Carlos III
funder
Pfizer
funder
Junta de Castilla y León (España)
2020-08-10T08:33:16Z
2020-08-10T08:33:16Z
2020
Front Med (Lausanne) . 2020 May 14;7:186.
10.3389/fmed.2020.00186
2296-858X
Frontiers in Medicine
32478085
http://hdl.handle.net/20.500.12105/10878
Interferon lambda 3 (IFNL3, previously called IL-28B) is a cytokine with effects against viral and bacterial pathogens. We aimed to analyze the IFNL3 rs12980275 SNP in patients who underwent major surgery, in order to establish its relationship with susceptibility to septic shock and septic shock-related death in these patients. We performed a case-control study on 376 patients to establish the association between IFNL3 rs12980275 SNP and the susceptibility to develop septic shock. Besides, we performed a longitudinal study among 172 septic shock patients using survival analysis with one censoring point of 28-days mortality. The IFNL3 rs12980275 polymorphism was genotyped by Agena Bioscience's MassARRAY platform. IFNL3 rs12980275 polymorphism was not associated with higher susceptibility to infection and septic shock development. Regarding survival analysis, the Kaplan-Meier analysis showed that patients with IFNL3 rs12980275 AA genotype had higher survival than patients with GG genotype (p = 0.003). The Cox regression analysis adjusted by the most relevant clinical and epidemiological characteristics showed that the GG genotype (recessive model) and the presence of the G allele (additive model) were associated with higher risk of death [adjusted hazard ratio (aHR) = 2.15, p = 0.034; aHR = 1.50, p = 0.030, respectively]. In conclusion, IFNL3 rs12980275 polymorphism was associated with septic shock-related death in patients who underwent major surgery. The A allele was linked to protection, and the G allele was associated with an increased risk of death. This is a first preliminary study that suggests for the first time a role of IFNL3 polymorphisms in the prognosis of septic shock.
eng
IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study
research article
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IFNL3Rs12980275PolymorphismPredicts_2020.pdf
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https://repisalud.isciii.es/bitstreams/222b32a5-f4a8-484a-a0dd-a9a6b3144a9e/download
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text/plain
IFNL3Rs12980275PolymorphismPredicts_2020.pdf.txt