2026-06-14T03:41:05Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/108612025-04-03T17:33:37Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978
Repisalud
author
Salgüero Fernandez, Sergio
author
González-García, Juan
author
Berenguer, Juan
author
Montes, María L
author
Díez, Cristina
author
Llop-Herrera, Elba
author
Pérez-Latorre, Leire
author
Bellón, José María
author
Medrano, Luz Maria
author
Garcia-Broncano, Pilar
author
Jimenez-Sousa, Maria Angeles
author
Resino, Salvador
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
2020-08-10T08:27:50Z
2020-08-10T08:27:50Z
2020-06-25
Sci Rep . 2020 Jun 25;10(1):10384.
10.1038/s41598-020-67159-3
2045-2322
Scientific reports
32587340
http://hdl.handle.net/20.500.12105/10861
We aimed to evaluate the association of plasma biomarkers linked to inflammation (bacterial translocation, inflammatory response, and endothelial dysfunction), coagulopathy, and angiogenesis with the severity of liver cirrhosis (assessed by the Child-Pugh-Turcotte score, CTP) and Child-Pugh B cirrhosis (CTP 7-9) in patients with advanced hepatitis C virus (HCV)-related cirrhosis. We carried out a cross-sectional study in 97 patients with advanced HCV-related cirrhosis (32 HCV-monoinfected and 65 HIV/HCV-coinfected). Plasma biomarkers were measured by ProcartaPlex multiplex immunoassays. The outcome variable was the CTP score and the Child-Pugh B cirrhosis (CTP 7-9). HIV/HCV-coinfected patients and HCV-monoinfected patients with advanced HCV-related cirrhosis had near-equivalent values of plasma biomarkers. Higher values of plasma biomarkers linked to an inflammatory response (IP-10, IL-8, IL-6, and OPG), endothelial dysfunction (sVCAM-1 and sICAM-1), and coagulopathy (D-dimer) were related to higher CTP values. The most significant biomarkers to detect the presence of Child-Pugh B cirrhosis (CTP 7-9) were IP-10 (p-value= 0.008) and IL-6 (p-value=0.002). The AUC-ROC values of IP-10, IL-6, and both biomarkers combined (IP-10+IL-6) were 0.78, 0.88, and 0.96, respectively. In conclusion, HIV infection does not appear to have a significant impact on the analyzed plasma biomarkers in patients with advanced HCV-related cirrhosis. However, plasma biomarkers linked to inflammation (inflammatory response and endothelial dysfunction) were related to the severity of liver cirrhosis (CTP score), mainly IP-10 and IL-6, which discriminated patients with Child-Pugh B concerning Child-Pugh A.
eng
Chemokines
nfectious diseases
Inflammation
Innate immunity
Hepatology
Hepatitis
HIV infections
Viral infection
Plasma IP-10 and IL-6 are linked to Child-Pugh B cirrhosis in patients with advanced HCV-related cirrhosis: a cross-sectional study
research article
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https://repisalud.isciii.es/bitstreams/20288461-be6e-4970-96a1-66fe841db69c/download
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PlasmaIP10And_2020.pdf
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https://repisalud.isciii.es/bitstreams/6191307b-6159-4fed-8f13-adec4673c00c/download
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PlasmaIP10And_2020.pdf.txt