2026-07-21T14:14:05Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/108572025-06-24T09:51:44Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16963col_20.500.12105_16971
Repisalud
author
Chalouni, Mathieu
author
Rodriguez-Centeno, Javier
author
Samri, Assia
author
Blanco, Julian
author
Stella-Ascariz, Natalia
author
Wallet, Cedrick
author
Knobel, Hernando
author
Zucman, David
author
Autran, Brigitte
author
Thiebaut, Rodolphe
author
Raffi, François
author
Arribas, José Ramón
author
Alejos, Belén
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-08-10T08:26:11Z
2020-08-10T08:26:11Z
2020
PLoS One . 2020 Apr 8;15(4):e0230772.
10.1371/journal.pone.0230772
1932-6203
PloS one
32267847
http://hdl.handle.net/20.500.12105/10857
In 31 participants who started first-line antiretroviral therapy in the NEAT 001/ANRS 143 clinical trial, we found after 96 weeks a statistically significant increase in blood telomere length (TL) of 0.04 (T/S Ratio) (p = 0.03). This increase was positively correlated with both the change in the percentage of CD4+ T-cells and with the decrease of CD38+ molecules on Central Memory CD8+ and negatively correlated with the change in the percentage of CD4+ Effector Memory cells. Increase in TL could be an expression of immune reconstitution and the associated decrease in immune activation. We acknowledge for the low statistical power due to the small sample size and the potential for false positive results due to multiple testing. Hence, further studies are needed to confirm these observations.
eng
Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1-positive individuals
research article
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URL
https://repisalud.isciii.es/bitstreams/6f993ce1-a081-4dc0-b506-4ea8c318aeb6/download
File
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application/pdf
CorrelationBetweenBloodTelomere_2020'.pdf
URL
https://repisalud.isciii.es/bitstreams/39f5709d-aeeb-4f5b-b54a-90d002dbe0a1/download
File
MD5
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text/plain
CorrelationBetweenBloodTelomere_2020'.pdf.txt