2026-06-14T03:45:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/108512025-05-29T11:13:36Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Gargini, Ricardo
author
Segura-Collar, Berta
author
Sánchez-Gómez, Pilar
funder
Asociación Española Contra el Cáncer
funder
Ministerio de Economía y Competitividad (España)
2020-08-03T18:49:39Z
2020-08-03T18:49:39Z
2020-06-18
Cancers (Basel) . 2020 Jun 18;12(6):1622.
10.3390/cancers12061622
2072-6694
Cancers
32570988
http://hdl.handle.net/20.500.12105/10851
Brain tumors encompass a diverse group of neoplasias arising from different cell lineages. Tumors of glial origin have been the subject of intense research because of their rapid and fatal progression. From a clinical point of view, complete surgical resection of gliomas is highly difficult. Moreover, the remaining tumor cells are resistant to traditional therapies such as radio- or chemotherapy and tumors always recur. Here we have revised the new genetic and epigenetic classification of gliomas and the description of the different transcriptional subtypes. In order to understand the progression of the different gliomas we have focused on the interaction of the plastic tumor cells with their vasculature-rich microenvironment and with their distinct immune system. We believe that a comprehensive characterization of the glioma microenvironment will shed some light into why these tumors behave differently from other cancers. Furthermore, a novel classification of gliomas that could integrate the genetic background and the cellular ecosystems could have profound implications in the efficiency of current therapies as well as in the development of new treatments.
eng
Glioblastoma
Lower grade glioma
IDH mutations
EGFR
Genetic and epigenetic alterations
Glioma subtypes
Tumor microenvironment
Endothelium
Pericytes
Blood-brain-barrier
Immune infiltrate
Tumor-associated-macrophages
Cellular Plasticity and Tumor Microenvironment in Gliomas: The Struggle to Hit a Moving Target
research article
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URL
https://repisalud.isciii.es/bitstreams/8c1eaebc-ecc2-4c02-ae81-7da07a9b1a1b/download
File
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application/pdf
CellularPlasticityaAndTumor_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/b3800559-4fd1-4101-8858-365da21f6a07/download
File
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text/plain
CellularPlasticityaAndTumor_2020.pdf.txt