2026-06-14T03:52:37Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/108512025-05-29T11:13:36Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Gargini, Ricardo author Segura-Collar, Berta author Sánchez-Gómez, Pilar author 2020-06-18 Brain tumors encompass a diverse group of neoplasias arising from different cell lineages. Tumors of glial origin have been the subject of intense research because of their rapid and fatal progression. From a clinical point of view, complete surgical resection of gliomas is highly difficult. Moreover, the remaining tumor cells are resistant to traditional therapies such as radio- or chemotherapy and tumors always recur. Here we have revised the new genetic and epigenetic classification of gliomas and the description of the different transcriptional subtypes. In order to understand the progression of the different gliomas we have focused on the interaction of the plastic tumor cells with their vasculature-rich microenvironment and with their distinct immune system. We believe that a comprehensive characterization of the glioma microenvironment will shed some light into why these tumors behave differently from other cancers. Furthermore, a novel classification of gliomas that could integrate the genetic background and the cellular ecosystems could have profound implications in the efficiency of current therapies as well as in the development of new treatments. Cancers (Basel) . 2020 Jun 18;12(6):1622. 10.3390/cancers12061622 2072-6694 Cancers 32570988 http://hdl.handle.net/20.500.12105/10851 Glioblastoma Lower grade glioma IDH mutations EGFR Genetic and epigenetic alterations Glioma subtypes Tumor microenvironment Endothelium Pericytes Blood-brain-barrier Immune infiltrate Tumor-associated-macrophages Cellular Plasticity and Tumor Microenvironment in Gliomas: The Struggle to Hit a Moving Target