2026-08-29T13:36:26Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/107022024-09-27T08:24:20Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Lolo, Fidel Nicolas
author
Jimenez-Jimenez, Victor
author
Sanchez-Alvarez, Miguel
author
del Pozo, Miguel Angel
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Worldwide Cancer Research
funder
Comunidad de Madrid (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación La Marató TV3
funder
Unión Europea
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Instituto de Salud Carlos III
2020-07-08T08:23:27Z
2020-07-08T08:23:27Z
2020-06
Cancer Metastasis Rev. 2020; 39:485–503
10.1007/s10555-020-09900-y
1573-7233
Cancer metastasis reviews
32514892
http://hdl.handle.net/20.500.12105/10702
Tumor stiffening is a hallmark of malignancy that actively drives tumor progression and aggressiveness. Recent research has shed light onto several molecular underpinnings of this biomechanical process, which has a reciprocal crosstalk between tumor cells, stromal fibroblasts, and extracellular matrix remodeling at its core. This dynamic communication shapes the tumor microenvironment; significantly determines disease features including therapeutic resistance, relapse, or metastasis; and potentially holds the key for novel antitumor strategies. Caveolae and their components emerge as integrators of different aspects of cell function, mechanotransduction, and ECM-cell interaction. Here, we review our current knowledge on the several pivotal roles of the essential caveolar component caveolin-1 in this multidirectional biomechanical crosstalk and highlight standing questions in the field.
eng
Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression.
journal article
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URL
https://repisalud.isciii.es/bitstreams/a94f3875-b9ee-4cec-8f73-342679380233/download
File
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application/pdf
Tumor-StromaBiomechanicalCrosstalk_2020..pdf
URL
https://repisalud.isciii.es/bitstreams/9841b9db-0c5a-4963-80e8-f1a42d047c38/download
File
MD5
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text/plain
Tumor-StromaBiomechanicalCrosstalk_2020..pdf.txt