2026-05-21T23:06:48Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/107022024-09-27T08:24:20Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Lolo, Fidel Nicolas author Jimenez-Jimenez, Victor author Sanchez-Alvarez, Miguel author del Pozo, Miguel Angel author 2020-06 Tumor stiffening is a hallmark of malignancy that actively drives tumor progression and aggressiveness. Recent research has shed light onto several molecular underpinnings of this biomechanical process, which has a reciprocal crosstalk between tumor cells, stromal fibroblasts, and extracellular matrix remodeling at its core. This dynamic communication shapes the tumor microenvironment; significantly determines disease features including therapeutic resistance, relapse, or metastasis; and potentially holds the key for novel antitumor strategies. Caveolae and their components emerge as integrators of different aspects of cell function, mechanotransduction, and ECM-cell interaction. Here, we review our current knowledge on the several pivotal roles of the essential caveolar component caveolin-1 in this multidirectional biomechanical crosstalk and highlight standing questions in the field. Cancer Metastasis Rev. 2020; 39:485–503 10.1007/s10555-020-09900-y 1573-7233 Cancer metastasis reviews 32514892 http://hdl.handle.net/20.500.12105/10702 Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression.