2026-07-21T14:26:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/106962025-06-18T07:07:04Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Mirones, Isabel
author
Mariñas-Pardo, Luis
author
Melen, Gustavo J
author
Ramírez, Manuel
author
Rodriguez-Milla, Miguel A
author
Cubillo, Isabel
author
Garcia-Castro, Javier
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
2020-07-07T20:36:32Z
2020-07-07T20:36:32Z
2012-08
Int J Mol Med . 2012 Aug;30(2):365-73.
10.3892/ijmm.2012.1008
1791-244X
International journal of molecular medicine
22641458
http://hdl.handle.net/20.500.12105/10696
Neuroblastoma (NB) is one of the most common pediatric solid tumors and, like most human cancers, is char-acterized by a broad variety of genomic alterations. Although mesenchymal stem cells (MSCs) are known to interact with cancer cells, the relationship between MSCs and metastatic NB cancer cells in bone marrow (BM) is unknown. To obtain genetic evidence about this interaction, we isolated ΒΜ-derived MSCs from children with NB and compared their global expression patterns with MSCs obtained from normal pediatric donors, using the Agilent 44K microarrays. Significance analysis of microarray results with a false discovery rate (FDR) <5% identified 496 differentially expressed genes showing either a 2-fold upregulation or downregulation between both groups of samples. Comparison of gene ontology categories of differ-entially expressed genes revealed the upregulation of genes categorized as ‘neurological system process’, ‘cell adhesion’, ‘apoptosis’, ‘cell surface receptor linked signal transduction’, ‘intrinsic to membrane’ and ‘extracellular region’. Among the downregulated genes, several immunology-related terms were the most abundant. These findings provide preliminary genetic evidence of the interaction between MSCs and NB cancer cells in ΒΜ as well as identify relevant biological processes potentially altered in MSCs in response to NB
eng
Enrichment of neural-related genes in human mesenchymal stem cells from neuroblastoma patients
research article
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EnrichmentOfNeuralRelated_2012.pdf
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https://repisalud.isciii.es/bitstreams/60d42f25-b9e9-4246-b509-ecae03a21ee8/download
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EnrichmentOfNeuralRelated_2012.pdf.txt