2026-08-29T19:27:46Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/106662025-05-08T15:15:43Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16962col_20.500.12105_19616col_20.500.12105_16986
Repisalud
author
Moreno, R
author
Vilardell Villellas, Felip
author
Cervera Soriano, Vanessa
author
Rojas, L. A.
author
Fajardo, C. A.
author
Alemany, Ramón
author
Garcia-Castro, Javier
funder
Asociación Española Contra el Cáncer
funder
Ministerio de Economía y Competitividad (España)
funder
Government of Catalonia (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-07-06T15:08:04Z
2020-07-06T15:08:04Z
2017
Stem Cells Int . 2017;2017:3615729.
10.1155/2017/3615729
1687-9678
1687-966X
Stem cells international
28781596
http://hdl.handle.net/20.500.12105/10666
Antitumor efficacy of systemically administered oncolytic adenoviruses (OAdv) is limited due to diverse factors such as liver sequestration, neutralizing interactions in blood, elimination by the immune system, and physical barriers in tumors. It is therefore of clinical relevance to improve OAdv bioavailability and tumor delivery. Among the variety of tumor-targeting strategies, the use of stem cells and specifically bone marrow-derived mesenchymal stem cells (BM-MSCs) is of particular interest due to their tumor tropism and immunomodulatory properties. Nonetheless, the invasive methods to obtain these cells, the low number of MSCs present in the bone marrow, and their restricted in vitro expansion represent major obstacles for their use in cancer treatments, pointing out the necessity to identify an alternative source of MSCs. Here, we have evaluated the use of menstrual blood-derived mesenchymal stem cells (MenSCs) as cell carriers for regional delivery of an OAdv in the tumor. Our results indicate that MenSCs can be isolated without invasive methods, they have an increased proliferation rate compared to BM-MSCs, and they can be efficiently infected with different serotype 5-based capsid-modified adenoviruses, leading to viral replication and release. In addition, our in vivo studies confirmed the tumor-homing properties of MenSCs after regional administration.
eng
Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus
research article
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URL
https://repisalud.isciii.es/bitstreams/292df917-0bbd-48da-aee0-a48f8b6cb056/download
File
MD5
14ade2eca251546da851e08a7da9dcfa
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application/pdf
HumanMenstrualBloodDerived_21017.pdf
URL
https://repisalud.isciii.es/bitstreams/efc15fe7-9515-4124-8df5-7b53f6f24e03/download
File
MD5
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text/plain
HumanMenstrualBloodDerived_21017.pdf.txt