2026-06-14T03:32:11Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/106562025-01-10T12:45:16Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Lorente, Elena author Infantes, Susana author Barnea, Eilon author Beer, Ilan author Garcia, Ruth author Admon, Arie author Lasala, Fátima author Jimenez, Mercedes author Lopez, Daniel author 2011-01-14 Individuals with nonfunctional transporters associated with antigen processing (TAP) complexes are not particularly susceptible to viral infections or neoplasms. Therefore, their immune system must be reasonably efficient, and the present, though reduced, cytolytic CD8 αβ T subpopulation specific for TAP-independent antigens may be sufficient to establish an immune defense protecting against viral infections in these individuals. The objective of the present study was to identify TAP-independent ligands from HIV gp160 protein. An analysis and comparison of complex human histocompatibility complex (HLA)-bound peptide pools isolated from large quantities of healthy or HIV gp160-expressing human cells was performed using mass spectrometry and bioinformatics tools. A conserved TAP-independent HLA peptide ligand endogenously processed and presented in infected human cells was identified. This ligand originates from the envelope protein bound to the HLA-Cw1 class I molecule with high affinity. It was concluded that HLA class I peptides derived from a large fraction of the N-terminal HIV envelope protein could be presented even in the absence of the TAP complex. AIDS . 2011 Jan 14;25(2):265-9. 10.1097/QAD.0b013e328340fe3c 1473-5571 0269-9370 AIDS (London, England) 21099670 http://hdl.handle.net/20.500.12105/10656 TAP-independent human histocompatibility complex-Cw1 antigen processing of an HIV envelope protein conserved peptide.