2026-06-14T03:44:37Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/106542025-05-23T11:30:15Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Angel Rico, Miguel
author
Trento, Alfonsina
author
Melero, Jose Antonio
author
Ramos, Manuel
author
Johnstone, Carolina
author
Val, Margarita del
author
Lopez, Daniel
funder
Ministerio de Educación y Ciencia (España)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
2020-07-06T05:53:33Z
2020-07-06T05:53:33Z
2009
Immunol Cell Biol . May-Jun 2009;87(4):344-50.
10.1038/icb.2008.109
0818-9641
Immunology and cell biology
19153593
http://hdl.handle.net/20.500.12105/10654
Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. Although human airway epithelial cells are the main target of HRSV, it has been reported that this virus can also infect professional antigen-presenting cells such as macrophages and dendritic cells, promoting upregulation of maturation markers. Here, we report that mouse spleen B220(+) B lymphocytes were susceptible to HRSV infection in vitro, probably involving a glycosaminoglycan-dependent mechanism. In contrast, neither CD4(+) nor CD8(+) T lymphocytes were infected. In B lymphocytes, HRSV infection upregulated major histocompatibility complex (MHC) class II but not MHC class I molecules and induced the expression of the activation marker CD86.
eng
Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes
research article
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URL
https://repisalud.isciii.es/bitstreams/3bc71616-73b0-45c2-ab38-b7bbf05a4f0b/download
File
MD5
8085d2920ace2c9679f27d54fd24f9d1
539177
application/pdf
HumanRespiratorySyncytialVirus_2009.pdf
URL
https://repisalud.isciii.es/bitstreams/e196d152-a98c-4aed-a7bf-b2ba6e3f18f6/download
File
MD5
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text/plain
HumanRespiratorySyncytialVirus_2009.pdf.txt