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oai:repisalud.isciii.es:20.500.12105/106542025-05-23T11:30:15Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Angel Rico, Miguel author Trento, Alfonsina author Melero, Jose Antonio author Ramos, Manuel author Johnstone, Carolina author Val, Margarita del author Lopez, Daniel author 2009 Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. Although human airway epithelial cells are the main target of HRSV, it has been reported that this virus can also infect professional antigen-presenting cells such as macrophages and dendritic cells, promoting upregulation of maturation markers. Here, we report that mouse spleen B220(+) B lymphocytes were susceptible to HRSV infection in vitro, probably involving a glycosaminoglycan-dependent mechanism. In contrast, neither CD4(+) nor CD8(+) T lymphocytes were infected. In B lymphocytes, HRSV infection upregulated major histocompatibility complex (MHC) class II but not MHC class I molecules and induced the expression of the activation marker CD86. Immunol Cell Biol . May-Jun 2009;87(4):344-50. 10.1038/icb.2008.109 0818-9641 Immunology and cell biology 19153593 http://hdl.handle.net/20.500.12105/10654 Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes