2026-04-29T00:59:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/106282025-06-17T08:54:43Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Mirones, Isabel
author
Mariñas-Pardo, Luis
author
de la Cueva, Teresa
author
Zapata, Agustín
author
Gonzalez, Carlos
author
Ramírez, Manuel
author
Rodriguez-Milla, Miguel A
author
Cubillo, Isabel
author
Garcia-Castro, Javier
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
funder
Regional Government of Andalusia (España)
2020-07-01T18:50:25Z
2020-07-01T18:50:25Z
2014-09
Stem Cells . 2014 Sep;32(9):2529-38.
1066-5099
http://hdl.handle.net/20.500.12105/10628
24806705
10.1002/stem.1745
1549-4918
Stem cells (Dayton, Ohio)
As the nervous system exerts direct and indirect effects on stem cells mobilization and catecholamines mobilize hematopoietic stem cells, we hypothesized that dopamine might induce mesenchymal progenitor cells (MPCs) mobilization. We show that dopamine induced in vitro MPCs migration through D2-class receptors, and their alternative phosphoinositide 3-kinase/Akt pathways. Also, administration of catecholamines induced in vivo mobilization of colony-forming unit-fibroblast in mice. In contrast, in vitro and in vivo MPCs migration was suppressed by D2-class receptors antagonists and blocking antibodies, consistent with dopamine signaling pathway implication. In humans, patients treated with L-dopa or catecholaminergic agonists showed a significant increase of a MPC-like population (CD45-CD31-CD34-CD105+) in their peripheral blood. These findings reveal a new link between catecholamines and MPCs mobilization and suggest the potential use of D2-class receptors agonists for mobilization of MPCs in clinical settings.
eng
Dopamine mobilizes mesenchymal progenitor cells through D2-class receptors and their PI3K/AKT pathway
research article
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URL
https://repisalud.isciii.es/bitstreams/cc15e63d-42f9-4017-be08-a1975e469483/download
File
MD5
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application/pdf
DopamineMobilizesMesenchymalProgenitor_2014.pdf
URL
https://repisalud.isciii.es/bitstreams/e679e40d-9364-4918-bd08-41f4c9f51acf/download
File
MD5
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text/plain
DopamineMobilizesMesenchymalProgenitor_2014.pdf.txt