2026-06-14T05:17:53Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/106202025-05-12T12:02:43Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16962col_20.500.12105_19616
Repisalud
author
Cejalvo, Teresa
author
Del Portillo, Isabel
author
Laborda, Eduardo
author
Vázquez, Fernando
author
Sardón, David
author
Ramirez, Manuel
author
Alemany, Ramón
author
Del Castillo, Noemí
author
Perise-Barrios, Ana Judith
author
Rodriguez-Milla, Miguel A
author
Cubillo, Isabel
author
Garcia-Castro, Javier
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
2020-06-30T21:07:24Z
2020-06-30T21:07:24Z
2018
Cancer Res. 2018 Sep 1;78(17):4891-4901.
10.1158/0008-5472.CAN-17-3754
1538-7445
Cancer research
29991502
http://hdl.handle.net/20.500.12105/10620
Dogs with spontaneous tumors treated in veterinary hospitals offer an excellent opportunity for studying immunotherapies, including oncolytic viruses. Oncolytic viruses have advanced into the clinic as an intratumorally administered therapeutic; however, intravenous delivery has been hindered by neutralization in the blood. To circumvent this hurdle, mesenchymal stem cells have been used as a "Trojan horse." Here, we present the treatment of 27 canine patients with cancer with canine mesenchymal stem cells infected with ICOCAV17, a canine oncolytic adenovirus. No significant adverse effects were found. The response rate was 74%, with 14.8% showing complete responses, including total remissions of lung metastasis. We detected virus infection, stromal degeneration, and immune cell infiltration in tumor biopsies after 4 weeks of treatment. The increased presence of antiadenoviral antibodies in the peripheral blood of treated dogs did not appear to prevent the clinical benefit of this therapy. These data indicate that oncolytic viruses loaded in mesenchymal stem cells represent an effective cancer immunotherapy.Significance: The classical clinical limitations of antitumoral viroimmunotherapy can be overcome by use of mesenchymal stem cells.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/78/17/4891/F1.large.jpg Cancer Res; 78(17); 4891-901. ©2018 AACR.
eng
Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy
research article
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URL
https://repisalud.isciii.es/bitstreams/77c2455e-93cf-449a-9834-400973283201/download
File
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application/pdf
RemissionOfSpontaneousCanine_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/bbd58228-88fe-44d2-bdec-897e53bb243d/download
File
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text/plain
RemissionOfSpontaneousCanine_2018.pdf.txt