2026-06-14T03:41:05Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/106082025-06-13T07:49:49Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617
Repisalud
author
Carro, Eva
author
Bartolomé, Fernando
author
Bermejo-Pareja, Félix
author
Villarejo-Galende, Alberto
author
Molina, José Antonio
author
Ortiz, Pablo
author
Calero, Miguel
author
Rábano, Alberto
author
Cantero, José Luis
author
Orive, Gorka
2020-06-29T17:07:23Z
2020-06-29T17:07:23Z
2017
Alzheimers Dement (Amst) . 2017 May 26;8:131-138.
10.1016/j.dadm.2017.04.002
2352-8729
2352-8729
Alzheimer's & dementia (Amsterdam, Netherlands)
28649597
http://hdl.handle.net/20.500.12105/10608
Introduction: The Alzheimer's disease (AD) process is likely initiated many years before clinical onset. Biomarkers of preclinical disease are critical for the development of disease-modifying or even preventative therapies. Current biomarkers for early disease, including cerebrospinal fluid tau and amyloid β (Aβ) levels, structural and functional magnetic resonance imaging, and the use of brain amyloid imaging, are limited because they are very invasive or expensive. Noninvasive biomarkers may be a more accessible alternative, but none can currently detect preclinical AD with the required sensitivity and specificity. Methods: Here, we show a novel, straight-forward, and noninvasive approach for assessment of early stages of cognitive decline. Salivary samples from cases of amnestic mild cognitive impairment (aMCI) and AD, and neurology controls were analyzed. Results: We have discovered and validated a new single saliva biomarker, lactoferrin, which in our cross-sectional investigation perfectly discriminates clinically diagnosed aMCI and AD patients from a cognitively healthy control group. The accuracy for AD diagnosis shown by salivary lactoferrin was greater than that obtained from core cerebrospinal fluid (CSF) biomarkers, including total tau and CSF Aβ42. Furthermore, salivary lactoferrin can be used for population screening and for identifying those underdiagnosed subjects with very early stages of mild cognitive impairment and AD. Conclusion: This biomarker may offer new insights in the early diagnostics for AD.
eng
Early diagnosis of mild cognitive impairment and Alzheimer's disease based on salivary lactoferrin
research article
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URL
https://repisalud.isciii.es/bitstreams/28cd0242-57e6-432f-95bb-6d2dbc9cc56f/download
File
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application/pdf
EarlyDiagnosisOfMild_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/56bdd088-c26f-426e-8f56-71e93cb19580/download
File
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text/plain
EarlyDiagnosisOfMild_2017.pdf.txt