2026-04-26T23:12:05Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/106072024-09-27T09:10:38Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Munoz-Canoves, Pura
author
Neves, Joana
author
Sousa-Victor, Pedro
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
2020-06-29T11:49:21Z
2020-06-29T11:49:21Z
2020-02
FEBS J. 2020; 287(3):406-416
http://hdl.handle.net/20.500.12105/10607
31854082
10.1111/febs.15182
1742-4658
The FEBS journal
Aging is characterized by the progressive dysfunction of most tissues and organs, which has been linked to the regenerative decline of their resident stem cells over time. Skeletal muscle provides a stark example of this decline. Its stem cells, also called satellite cells, sustain muscle regeneration throughout life, but at advanced age they fail for largely undefined reasons. Here, we discuss current understanding of the molecular processes regulating satellite cell maintenance throughout life and how age-related failure of these processes contributes to muscle aging. We also highlight the emerging field of rejuvenating biology to restore features of youthfulness in satellite cells, with the ultimate goal of slowing down or reversing the age-related decline in muscle regeneration.
eng
Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells.
journal article
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URL
https://repisalud.isciii.es/bitstreams/010da812-beef-4f0b-a79d-cdf31905f63b/download
File
MD5
44655b331211928fa76fd8a1881847d5
769432
application/pdf
UnderstandingMuscleRegenerativeDecline_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/f7403558-68b5-4ade-b7f4-4a96a33afc5e/download
File
MD5
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text/plain
UnderstandingMuscleRegenerativeDecline_2020.pdf.txt