2026-05-16T22:07:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/106052024-09-27T09:11:17Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Sousa-Victor, Pedro
author
García-Prat, Laura
author
Munoz-Canoves, Pura
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
European Molecular Biology Organization
funder
Glenn Foundation for Medical Research
funder
Fundación La Marató TV3
2020-06-29T11:11:25Z
2020-06-29T11:11:25Z
2018
Int J Dev Biol. 2018; 62(6-7-8):583-590
10.1387/ijdb.180041pm
1696-3547
The International journal of developmental biology
29938769
http://hdl.handle.net/20.500.12105/10605
Stem cells must preserve their function in order to sustain organ and tissue formation, homeostasis and repair. Adult stem cells, particularly those resident in tissues with little turnover, remain quiescent for most of their life, activating only in response to regenerative demands. Among the best studied long-lived quiescent stem cells are skeletal muscle stem cells, which are fully equipped to sustain repair in response to tissue trauma. Recent evidence indicates that the preservation of muscle stem-cell quiescence and regenerative capacity depends on intracellular networks linking metabolism and protein homeostasis. Here, we review recent research into how these networks control stem cell function and how their dysregulation contributes to aging, with a particular focus on senescence entry in extreme old age. We also discuss the implications of these new findings for anti-aging research in muscle stem-cell-based regenerative medicine.
eng
New mechanisms driving muscle stem cell regenerative decline with aging.
journal article
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URL
https://repisalud.isciii.es/bitstreams/a58fdee5-ab00-473b-aaf6-60cbb815c7f1/download
File
MD5
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application/pdf
NewMechanismsDrivingMuscle_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/8db5580d-bfa0-4b66-b8df-ddbccb770f56/download
File
MD5
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text/plain
NewMechanismsDrivingMuscle_2018.pdf.txt