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oai:repisalud.isciii.es:20.500.12105/105482024-09-27T22:47:52Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Lopez, Daniel author Lorente, Elena author Barriga, Alejandro author Johnstone, Carolina author Mir-Gerrero, Carmen author 2013-09 The cytotoxic CD8(+) T lymphocyte-mediated cellular response is important for the elimination of virus-infected cells and requires the prior recognition of short viral peptide antigens previously translocated to the endoplasmic reticulum by the transporter associated with antigen processing (TAP). However, individuals with nonfunctional TAP complexes or infected cells with TAP molecules blocked by specific viral proteins, such as the cowpoxvirus, a component of the first source of early empirical vaccination against smallpox, are still able to present several HLA class I ligands generated by the TAP-independent antigen processing pathways to specific cytotoxic CD8(+) T lymphocytes. Currently, bioterrorism and emerging infectious diseases have renewed interest in poxviruses. Recent works that have identified HLA class I ligands and epitopes in virus-infected TAP-deficient cells have implications for the study of both the effectiveness of early empirical vaccination and the analysis of HLA class I antigen processing in TAP-deficient subjects. Expert Rev Vaccines . 2013 Sep;12(9):1077-83 10.1586/14760584.2013.825447 1744-8395 1476-0584 Expert review of vaccines 24053400 http://hdl.handle.net/20.500.12105/10548 Vaccination and the TAP-independent antigen processing pathways.