2026-06-14T03:40:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/104932024-09-27T08:03:57Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
García-Prat, Laura
author
Munoz-Canoves, Pura
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Pompeu Fabra University (España)
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Fundación La Marató TV3
2020-06-18T11:32:14Z
2020-06-18T11:32:14Z
2017-04
Mol Cell Endocrinol. 2017; 445:109-117
10.1016/j.mce.2016.08.021
1872-8057
Molecular and cellular endocrinology
27531569
http://hdl.handle.net/20.500.12105/10493
All tissues and organs undergo a progressive regenerative decline as they age. This decline has been mainly attributed to loss of stem cell number and/or function, and both stem cell-intrinsic changes and alterations in local niches and/or systemic environment over time are known to contribute to the stem cell aging phenotype. Advancing in the molecular understanding of the deterioration of stem cell cells with aging is key for targeting the specific causes of tissue regenerative dysfunction at advanced stages of life. Here, we revise exciting recent findings on why stem cells age and the consequences on tissue regeneration, with a special focus on regeneration of skeletal muscle. We also highlight newly identified common molecular pathways affecting diverse types of aging stem cells, such as altered proteostasis, metabolism, or senescence entry, and discuss the questions raised by these findings. Finally, we comment on emerging stem cell rejuvenation strategies, principally emanating from studies on muscle stem cells, which will surely burst tissue regeneration research for future benefit of the increasing human aging population.
eng
Aging, metabolism and stem cells: Spotlight on muscle stem cells.
journal article
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URL
https://repisalud.isciii.es/bitstreams/9bef076f-c940-4c9f-986f-23e58a77a370/download
File
MD5
c3a0404855a5bbc6aade506fce213f70
633501
application/pdf
AgingMetabolismStemCells_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/d182205e-0128-44bd-8b00-a5d38e48c353/download
File
MD5
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text/plain
AgingMetabolismStemCells_2017.pdf.txt