2026-06-14T03:46:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/104902024-09-27T09:54:49Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Menchero, Sergio
author
Sainz de Aja, Julio
author
Manzanares, Miguel
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
2020-06-18T07:21:55Z
2020-06-18T07:21:55Z
2018-02
Curr Top Dev Biol. 2018; 128:59-80
10.1016/bs.ctdb.2017.10.009
1557-8933
Current topics in developmental biology
29477171
http://hdl.handle.net/20.500.12105/10490
The trophectoderm (TE) is the first cell population to appear in the mammalian preimplantation embryo, as the result of the differentiation of totipotent blastomeres located on the outer surface of the late morula. Trophectodermal cells arrange in a monolayer covering the expanding blastocyst and acquire an epithelial phenotype with distinct apicobasal polarity and a basal lamina placed toward the blastocyst interior. During later development through the periimplantation and gastrulation stages, the TE gives rise to extraembryonic membranes and cell types that will eventually form most of the fetal placenta, the specialized organ through which the embryo obtains maternal nourishment necessary for subsequent exponential growth. The specification of the TE is controlled by the combination of morphological cues arising from cell polarity with differential activity of signaling pathways such as Hippo and Notch, and the restriction to outer cells of lineage specifiers such as CDX2. This is possibly the first symmetry-breaking decision undertaken by the uncommitted cells produced by a handful of mitosis divisions from the newly fertilized zygote. Understanding how this cell lineage is specified will therefore provide unique information about development, differentiation, and how the interplay between cellular morphology and signaling and regulatory factors results in a correctly 3D-patterned embryo.
eng
Our First Choice: Cellular and Genetic Underpinnings of Trophectoderm Identity and Differentiation in the Mammalian Embryo.
journal article
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URL
https://repisalud.isciii.es/bitstreams/48a03617-518b-45ad-b5ec-aaf7a37d79b2/download
File
MD5
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application/pdf
OurFirstChoiceCellular_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/2fac0ed0-acec-45d9-80a0-8c6e4445e29f/download
File
MD5
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text/plain
OurFirstChoiceCellular_2018.pdf.txt