2026-04-29T23:03:56Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/104842024-09-27T08:09:02Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Menchero, Sergio
author
Rayon, Teresa
author
Andreu, Maria Jose
author
Manzanares, Miguel
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación ProCNIC
2020-06-18T06:58:49Z
2020-06-18T06:58:49Z
2017-04
Dev Dyn. 2017; 246(4):245-261
10.1002/dvdy.24471
1097-0177
Developmental dynamics : an official publication of the American Association of Anatomists
27859869
http://hdl.handle.net/20.500.12105/10484
The first stages of mammalian development, before implantation of the embryo in the maternal uterus, result in the establishment of three cell populations in the blastocyst: trophectoderm, epiblast, and primitive endoderm. These events involve only a small number of cells, and are initiated by morphological differences among them related to cell adhesion and polarity. Much attention has been paid to the master transcription factors that are critical for establishing and maintaining early lineage choices. Nevertheless, a large body of work also reveals that additional molecular mechanisms are involved. Here, we provide an updated view of the role of different signaling pathways in the first stages of mouse development, and how their cross-talk and interplay determine the initial lineage decisions occurring in the blastocyst. We will also discuss how these pathways are critical for translating cellular phenotypes, the product of the morphogenetic events occurring at these stages, into transcriptional responses and expression of lineage-specifying transcription factors. Developmental Dynamics 246:245-261, 2017. © 2016 Wiley Periodicals, Inc.
eng
Signaling pathways in mammalian preimplantation development: Linking cellular phenotypes to lineage decisions.
journal article
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URL
https://repisalud.isciii.es/bitstreams/f9951a6d-c253-4d74-9500-ed1d555fae16/download
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application/pdf
SignalingPathwaysMammalianPreimplantation_2017..pdf
URL
https://repisalud.isciii.es/bitstreams/2770a38e-edd1-47fe-b914-0a9e8d333dfe/download
File
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SignalingPathwaysMammalianPreimplantation_2017..pdf.txt