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oai:repisalud.isciii.es:20.500.12105/104482025-05-08T06:28:14Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc De Ory, Fernando de author Avellón, Ana author Echevarria, Juan Emilio author Sánchez-Seco, María Paz author Trallero, Gloria author Cabrerizo, Maria author Casas Flecha, Inmaculada author Pozo Sanchez, Francisco author Fedele, Cesare Giovanni author Vicente, D author Pena, María José author Moreno, A author Niubo, J author Rabella, Nuria author Rubio, G author Pérez-Ruiz, M author Rodríguez-Iglesias, M author Gimeno, C author Eiros, José María author Melón, S author Blasco, M author López-Miragaya, Isabel author Varela, E author Martínez-Sapiña, Ana author Rodriguez, G author Marcos, Á author Gegúndez, M I author Cilla, G author Gabilondo, I author Navarro, J M author Torres, J author Aznar-Lopez, Carolina author Castellanos-Nadal, Ana Maria author Guisasola, Maria Eulalia author Negredo, Anabel author Tenorio, Antonio author Vázquez-Morón, Sonia author 2013-03 The aim of the study was to determine the incidence of viruses causing aseptic meningitis, meningoencephalitis, and encephalitis in Spain. This was a prospective study, in collaboration with 17 Spanish hospitals, including 581 cases (CSF from all and sera from 280): meningitis (340), meningoencephalitis (91), encephalitis (76), febrile syndrome (7), other neurological disorders (32), and 35 cases without clinical information. CSF were assayed by PCR for enterovirus (EV), herpesvirus (herpes simplex [HSV], varicella-zoster [VZV], cytomegalovirus [CMV], Epstein-Barr [EBV], and human herpes virus-6 [HHV-6]), mumps (MV), Toscana virus (TOSV), adenovirus (HAdV), lymphocytic choriomeningitis virus (LCMV), West Nile virus (WNV), and rabies. Serology was undertaken when methodology was available. Amongst meningitis cases, 57.1% were characterized; EV was the most frequent (76.8%), followed by VZV (10.3%) and HSV (3.1%; HSV-1: 1.6%; HSV-2: 1.0%, HSV non-typed: 0.5%). Cases due to CMV, EBV, HHV-6, MV, TOSV, HAdV, and LCMV were also detected. For meningoencephalitis, 40.7% of cases were diagnosed, HSV-1 (43.2%) and VZV (27.0%) being the most frequent agents, while cases associated with HSV-2, EV, CMV, MV, and LCMV were also detected. For encephalitis, 27.6% of cases were caused by HSV-1 (71.4%), VZV (19.1%), or EV (9.5%). Other positive neurological syndromes included cerebellitis (EV and HAdV), seizures (HSV), demyelinating disease (HSV-1 and HHV-6), myelopathy (VZV), and polyradiculoneuritis (HSV). No rabies or WNV cases were identified. EVs are the most frequent cause of meningitis, as is HSV for meningoencephalitis and encephalitis. A significant number of cases (42.9% meningitis, 59.3% meningoencephalitis, 72.4% encephalitis) still have no etiological diagnosis. J Med Virol . 2013 Mar;85(3):554-62. 10.1002/jmv.23470 1096-9071 Journal of medical virology 23239485 http://hdl.handle.net/20.500.12105/10448 Viral infections of the central nervous system in Spain: a prospective study