2026-06-14T03:45:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/104172025-04-25T08:57:34Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16970
Repisalud
author
Iglesias-Escudero, María
author
Sansegundo-Arribas, David
author
Riquelme, Paloma
author
Merino-Fernández, David
author
Guiral-Foz, Sandra
author
Pérez, Carmen
author
Valero, Rosalia
author
Ruiz, Juan Carlos
author
Rodrigo, Emilio
author
Lamadrid-Perojo, Patricia
author
Hutchinson, James A
author
Lopez-Hoyos, Marcos
author
Ochando, Jordi
funder
Instituto de Salud Carlos III
funder
Unión Europea. Comisión Europea. H2020
2020-06-16T07:36:01Z
2020-06-16T07:36:01Z
2020
Front Immunol . 2020 Apr 30;11:643.
10.3389/fimmu.2020.00643
1664-3224
Frontiers in immunology
32425928
http://hdl.handle.net/20.500.12105/10417
Myeloid-derived suppressor cells (MDSC) represent a heterogeneous group of myeloid regulatory cells that were originally described in cancer. Several studies in animal models point to MDSC as important players in the induction of allograft tolerance due to their immune modulatory function. Most of the published studies have been performed in animal models, and the data addressing MDSCs in human organ transplantation are scarce. We evaluated the phenotype and function of different MDSCs subsets in 38 kidney transplant recipients (KTRs) at different time points. Our data indicate that monocytic MDSCs (Mo-MDSC) increase in KTR at 6 and 12 months posttransplantation. On the contrary, the percentages of polymorphonuclear MDSC (PMN-MDSC) and early-stage MDSC (e-MDSC) are not significantly increased. We evaluated the immunosuppressive activity of Mo-MDSC in KTR and confirmed their ability to increase regulatory T cells (Treg) in vitro. Interestingly, when we compared the ability of Mo-MDSC to suppress T cell proliferation, we observed that tacrolimus, but not rapamycin-treated KTR, was able to inhibit CD4+ T cell proliferation in vitro. This indicates that, although mTOR inhibitors are widely regarded as supportive of regulatory responses, rapamycin may impair Mo-MDSC function, and suggests that the choice of immunosuppressive therapy may determine the tolerogenic pathway and participating immune cells that promote organ transplant acceptance in KTR.
eng
Myeloid-Derived Suppressor Cells in Kidney Transplant Recipients and the Effect of Maintenance Immunotherapy
research article
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