2026-07-21T07:57:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/103952024-09-27T21:00:44Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Braza, Mounia S
author
Garcia, Mercedes
author
Brahmachary, Manisha
author
Pothula, Venu
author
Fay, Francois
author
Boros, Peter
author
Werner, Sherry A
author
Ginhoux, Florent
author
Mulder, Willem J M
author
Ochando, Jordi
author
Conde-San Román, Patricia
author
Cortegano, Isabel
funder
National Institutes of Health (Estados Unidos)
funder
Ministerio de Economía y Competitividad (España)
2020-06-15T06:22:07Z
2020-06-15T06:22:07Z
2018
Am J Transplant . 2018 May;18(5):1247-1255.
10.1111/ajt.14645
1600-6143
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
29314558
http://hdl.handle.net/20.500.12105/10395
The colony-stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1-mediated macrophage development remain to be elucidated. Here we demonstrate that neutrophil-derived CSF1 controls macrophage polarization and proliferation, which is necessary for the induction of tolerance. Inhibiting neutrophil production of CSF1 or preventing macrophage proliferation, using targeted nanoparticles loaded with the cell cycle inhibitor simvastatin, abrogates the induction of tolerance. These results provide new mechanistic insights into the developmental requirements of tolerogenic macrophages and identify CSF1 producing neutrophils as critical regulators of the immunological response.
eng
Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance.
journal article
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URL
https://repisalud.isciii.es/bitstreams/8f42528f-9ecf-48dd-974d-cad49059281f/download
File
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application/pdf
NeutrophilDerivedCSF1Induces_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/a338fc63-1894-4ff2-b6da-36979e72ed5e/download
File
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NeutrophilDerivedCSF1Induces_2018.pdf.txt