2026-06-14T03:44:55Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/103952024-09-27T21:00:44Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Braza, Mounia S author Garcia, Mercedes author Brahmachary, Manisha author Pothula, Venu author Fay, Francois author Boros, Peter author Werner, Sherry A author Ginhoux, Florent author Mulder, Willem J M author Ochando, Jordi author Conde-San Román, Patricia author Cortegano, Isabel author 2018 The colony-stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1-mediated macrophage development remain to be elucidated. Here we demonstrate that neutrophil-derived CSF1 controls macrophage polarization and proliferation, which is necessary for the induction of tolerance. Inhibiting neutrophil production of CSF1 or preventing macrophage proliferation, using targeted nanoparticles loaded with the cell cycle inhibitor simvastatin, abrogates the induction of tolerance. These results provide new mechanistic insights into the developmental requirements of tolerogenic macrophages and identify CSF1 producing neutrophils as critical regulators of the immunological response. Am J Transplant . 2018 May;18(5):1247-1255. 10.1111/ajt.14645 1600-6143 American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 29314558 http://hdl.handle.net/20.500.12105/10395 Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance.