2026-06-14T03:40:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/103912024-09-27T09:57:15Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Dosil, Sara G
author
Rojas-Gomez, Amelia
author
Sanchez-Madrid, Francisco
author
Martin-Cofreces, Noa B.
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Fundación Ramón Areces
funder
Fundación BBVA
funder
Fundación La Marató TV3
funder
Fundación La Caixa
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación ProCNIC
2020-06-12T13:44:38Z
2020-06-12T13:44:38Z
2020-04-19
Int J Mol Sci. 2020; 21(8):2859
10.3390/ijms21082859
1422-0067
International journal of molecular sciences
32325900
http://hdl.handle.net/20.500.12105/10391
The immune synapse (IS) is a well-known intercellular communication platform, organized at the interphase between the antigen presenting cell (APC) and the T cell. After T cell receptor (TCR) stimulation, signaling from plasma membrane proteins and lipids is amplified by molecules and downstream pathways for full synapse formation and maintenance. This secondary signaling event relies on intracellular reorganization at the IS, involving the cytoskeleton and components of the secretory/recycling machinery, such as the Golgi apparatus and the endolysosomal system (ELS). T cell activation triggers a metabolic reprogramming that involves the synthesis of lipids, which act as signaling mediators, and an increase of mitochondrial activity. Then, this mitochondrial activity results in elevated reactive oxygen species (ROS) production that may lead to cytotoxicity. The regulation of ROS levels requires the concerted action of mitochondria and peroxisomes. In this review, we analyze this reprogramming and the signaling implications of endolysosomal, mitochondrial, peroxisomal, and lipidic systems in T cell activation.
eng
The Swing of Lipids at Peroxisomes and Endolysosomes in T Cell Activation.
journal article
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URL
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SwingLipidsPeroxisomesEndolysosomes_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/a52bf63e-4531-4f0a-aefe-7810257df625/download
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SwingLipidsPeroxisomesEndolysosomes_2020.pdf.txt