2026-04-29T04:09:02Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/103752024-09-27T09:16:11Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Garcia-Lunar, Ines
author
Blanco, Isabel
author
Fernandez-Friera, Leticia
author
Prat-Gonzàlez, Susanna
author
Jordà, Paloma
author
Sánchez, Javier
author
Pereda, Daniel
author
Pujadas, Sandra
author
Rivas, Mercedes
author
Solé-Gonzalez, Eduard
author
Vázquez, Jorge
author
Blázquez, Zorba
author
García-Picart, Juan
author
Caravaca, Pedro
author
Escalera, Noemí
author
Garcia-Pavia, Pablo
author
Delgado, Juan
author
Segovia-Cubero, Javier
author
Fuster, Valentin
author
Roig, Eulalia
author
Barberá, Joan Albert
author
Ibáñez, Borja
author
Garcia-Alvarez, Ana
funder
Fundación La Marató TV3
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Government of Catalonia (España)
2020-06-12T09:28:43Z
2020-06-12T09:28:43Z
2020-04
JACC Basic Transl Sci. 2020; 5(4):317-327
http://hdl.handle.net/20.500.12105/10375
32368692
10.1016/j.jacbts.2020.01.009
2452-302X
JACC. Basic to translational science
Combined pre-and post-capillary hypertension (CpcPH) is a relatively common complication of heart failure (HF) associated with a poor prognosis. Currently, there is no specific therapy approved for this entity. Recently, treatment with beta-3 adrenergic receptor (β3AR) agonists was able to improve pulmonary hemodynamics and right ventricular (RV) performance in a translational, large animal model of chronic PH. The authors present the design of a phase II randomized clinical trial that tests the benefits of mirabegron (a clinically available β3AR agonist) in patients with CpcPH due to HF. The effect of β3AR treatment will be evaluated on pulmonary hemodynamics, as well as clinical, biochemical, and advanced cardiac imaging parameters. (Beta3 Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure [SPHERE-HF]; NCT02775539).
eng
Design of the β3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial.
journal article
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File
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application/pdf
DesignBeta3-AdrenergicAgonist_2020.pdf
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https://repisalud.isciii.es/bitstreams/3f18ac10-a2e9-4320-b632-b68ef82f982d/download
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text/plain
DesignBeta3-AdrenergicAgonist_2020.pdf.txt