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oai:repisalud.isciii.es:20.500.12105/103442024-10-31T11:56:55Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Rodríguez, Javier M author Luque, Daniel author 2019 To initiate infection, non-enveloped viruses must recognize a target cell and penetrate the cell membrane by pore formation or membrane lysis. Rotaviruses are non-enveloped dsRNA viruses that infect the mature intestinal epithelium. They are major etiologic agents of diarrheal disease in human infants, as well as in young individuals of various avian and mammalian species. Rotavirus entry into the cell is a complex multistep process initiated by the interaction of the tip of the viral spike with glycan ligands at the cell surface, and driven by conformational changes of the proteins present in the outer protein capsid, the viral machinery for entry. This review feeds on the abundant structural information produced for rotavirus during the past 30 years and focuses on the structure and the dynamics of the rotavirus entry machinery. We survey the current models for rotavirus entry into cells. Adv Exp Med Biol . 2019;1215:45-68. 10.1007/978-3-030-14741-9_3 0065-2598 Advances in experimental medicine and biology 31317495 http://hdl.handle.net/20.500.12105/10344 Structural Insights into Rotavirus Entry