2026-06-14T03:31:48Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/103182025-05-20T08:40:50Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_19605col_20.500.12105_19616

00925njm 22002777a 4500 dc Sreenivasan, Krishnamoorthy author Ianni, Alessandro author Künne, Carsten author Strilic, Boris author Günther, Stefan author Perdiguero, Eusebio author Krüger, Marcus author Spuler, Simone author Offermanns, Stefan author Gomez-del Arco, Pablo author Gómez-Del Arco, Pablo author Redondo, Juan Miguel author Munoz-Canoves, Pura author Kim, Johnny author Braun, Thomas author 2020-05-19 Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore organ function is not fully understood. Here, we show that a substantial fraction of muscle stem cells (MuSCs) undergo necroptosis because of epigenetic rewiring during chronic skeletal muscle regeneration, which is required for efficient regeneration of dystrophic muscles. Inhibition of necroptosis strongly enhances suppression of MuSC expansion in a non-cell-autonomous manner. Prevention of necroptosis in MuSCs of healthy muscles is mediated by the chromatin remodeler CHD4, which directly represses the necroptotic effector Ripk3, while CHD4-dependent Ripk3 repression is dramatically attenuated in dystrophic muscles. Loss of Ripk3 repression by inactivation of Chd4 causes massive necroptosis of MuSCs, abolishing regeneration. Our study demonstrates how programmed cell death in MuSCs is tightly controlled to achieve optimal tissue regeneration. Cell Rep. 2020; 31(7):107652 10.1016/j.celrep.2020.107652 2211-1247 Cell reports 32433961 http://hdl.handle.net/20.500.12105/10318 Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles.