2026-06-30T02:01:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/103132024-11-29T16:05:49Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
González-García, Mary-Paz
author
Pavelescu, Irina
author
Sevillano, Xavier
author
Leehy, Katherine A
author
Nelson, Andrew D L
author
Ibañes, Marta
author
Shippen, Dorothy E
author
Caño-Delgado, Ana I
author
Blasco, MA
funder
NIH - National Cancer Institute (NCI) (Estados Unidos)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Unión Europea
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Fundación AXA
funder
Government of Catalonia (España)
funder
European Molecular Biology Organization
funder
Botín Foundation
2020-06-09T16:58:27Z
2020-06-09T16:58:27Z
2015-05-12
Cell Rep . 2015 ;11(6):977-989.
10.1016/j.celrep.2015.04.013
2211-1247
Cell reports
25937286
http://hdl.handle.net/20.500.12105/10313
Telomeres are specialized nucleoprotein caps that protect chromosome ends assuring cell division. Single-cell telomere quantification in animals established a critical role for telomerase in stem cells, yet, in plants, telomere-length quantification has been reported only at the organ level. Here, a quantitative analysis of telomere length of single cells in Arabidopsis root apex uncovered a heterogeneous telomere-length distribution of different cell lineages showing the longest telomeres at the stem cells. The defects in meristem and stem cell renewal observed in tert mutants demonstrate that telomere lengthening by TERT sets a replicative limit in the root meristem. Conversely, the long telomeres of the columella cells and the premature stem cell differentiation plt1,2 mutants suggest that differentiation can prevent telomere erosion. Overall, our results indicate that telomere dynamics are coupled to meristem activity and continuous growth, disclosing a critical association between telomere length, stem cell function, and the extended lifespan of plants.
eng
Single-cell telomere-length quantification couples telomere length to meristem activity and stem cell development in Arabidopsis.
journal article
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Single-CellTelomere-LengthQuantification_2015.pdf.txt
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