2026-07-23T20:34:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/103082024-09-27T07:56:13Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Porcuna, Jesus
author
Menendez-Gutierrez, Maria Piedad
author
Ricote, Mercedes
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación La Marató TV3
funder
Comunidad de Madrid (España)
funder
Fundación ProCNIC
2020-06-09T14:26:56Z
2020-06-09T14:26:56Z
2020-05-08
Curr Opin Pharmacol. 2020; 53:27-34
10.1016/j.coph.2020.04.001
1471-4973
Current opinion in pharmacology
32403022
http://hdl.handle.net/20.500.12105/10308
Macrophages are key immune cells that reside in almost all tissues of the body, where they exert pleiotropic functions in homeostasis and disease. Development and identity of macrophages in each organ are governed by tissue-dependent signaling pathways and transcription factors that ultimately define specific tissue-resident macrophage phenotypes and functions. In recent years, nuclear receptors, a class of ligand-activated transcription factors, have been found to play important roles in macrophage specification in several tissues. Nuclear receptors are thus important targets for therapies aimed at controlling the numbers and functions of tissue-resident macrophages. This review outlines current knowledge about the critical roles of nuclear receptors in tissue-resident macrophage development, specification, and maintenance.
eng
Molecular control of tissue-resident macrophage identity by nuclear receptors.
journal article
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URL
https://repisalud.isciii.es/bitstreams/8d0b9d46-7fec-44d6-99b4-4759c0f50e98/download
File
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application/pdf
MolecularControlTtissue-resident_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/ad48c1f4-f677-440d-9003-cdd9c3888ee1/download
File
MD5
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text/plain
MolecularControlTtissue-resident_2020.pdf.txt