2026-06-30T02:01:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/103042025-04-29T09:04:39Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16961
Repisalud
author
Coiras, Mayte
author
Ambrosioni, Juan
author
Cervantes, Francisco
author
Miró, José María
author
Alcamí, José
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-06-09T10:53:30Z
2020-06-09T10:53:30Z
2017-05
Expert Opin Drug Saf. 2017 May;16(5):547-559.
10.1080/14740338.2017.1313224
1744-764X
1474-0338
Expert opinion on drug safety
28387147
http://hdl.handle.net/20.500.12105/10304
INTRODUCTION: Infection caused by HIV-1 is nowadays a chronic disease due to a highly efficient antiretroviral treatment that is nevertheless, unable to eliminate the virus from the organism. New strategies are necessary in order to impede the formation of the viral reservoirs, responsible for the failure of the antiretroviral treatment to cure the infection. Areas covered: The purpose of this review is to discuss the possibility of using tyrosine kinase inhibitors (TKIs) for the treatment of HIV-1 infection. These inhibitors are successfully used in patients with distinct cancers such as chronic myeloid leukemia. The most relevant papers have been selected and commented. Expert opinion: The family of TKIs are directed against the activation of tyrosine kinases from the Src family. Some of these kinases are essential for the activation of CD4 + T cells, the major target of HIV-1. During acute or primary infection the CD4 + T cells are massively activated, which is mostly responsible for the generation of the reservoirs, the spread of the infection and the destruction of activated CD4 + T cells, infected or not. Consequently, we discuss the possibility of using TKIs as adjuvant of the antiretroviral treatment against HIV-1 infection mostly, but not exclusively, during the acute/recent phase.
eng
HIV/AIDS
T-cell activation
Tyrosine kinase inhibitors
Chronic myeloid leukemia
Immunomodulation
Viral reservoirs
Tyrosine kinase inhibitors: potential use and safety considerations in HIV-1 infection
research article
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URL
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TyrosineKinaseInhibitorsPotential_2017.pdf
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https://repisalud.isciii.es/bitstreams/4a04042d-6487-4ad0-9c8f-5c5542ea2bad/download
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TyrosineKinaseInhibitorsPotential_2017.pdf.txt