2026-06-14T03:53:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/102912024-11-29T13:58:29Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Stanczuk, Lukas
author
Martinez-Corral, Ines
author
Ulvmar, Maria H
author
Zhang, Yang
author
Laviña, Bàrbara
author
Fruttiger, Marcus
author
Adams, Ralf H
author
Saur, Dieter
author
Betsholtz, Christer
author
Alitalo, Kari
author
Graupera, Mariona
author
Mäkinen, Taija
funder
European Molecular Biology Organization
funder
Kjell och Märta Beijers Stiftelse
funder
Swedish Research Council
funder
Fundación Alfonso Martín Escudero
funder
Ministerio de Economía y Competitividad (España)
funder
Medical Research Council (Reino Unido)
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Knut and Alice Wallenberg Foundation
funder
Fondation Leducq
funder
Swedish Cancer Foundation
2020-06-08T17:05:13Z
2020-06-08T17:05:13Z
2015-03-17
Cell Rep .2015 ;10(10):1708-1721
10.1016/j.celrep.2015.02.026
2211-1247
Cell reports
25772358
http://hdl.handle.net/20.500.12105/10291
Pathological lymphatic diseases mostly affect vessels in specific tissues, yet little is known about organ-specific regulation of the lymphatic vasculature. Here, we show that the vascular endothelial growth factor receptor 3 (VEGFR-3)/p110α PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature. Using genetic lineage tracing, we demonstrate that part of the mesenteric lymphatic vasculature develops from cKit lineage cells of hemogenic endothelial origin through a process we define as lymphvasculogenesis. This is contrary to the current dogma that all mammalian lymphatic vessels form by sprouting from veins. Our results reveal vascular-bed-specific differences in the origin and mechanisms of vessel formation, which may critically underlie organ-specific manifestation of lymphatic dysfunction in disease. The progenitor cells identified in this study may be exploited to restore lymphatic function following cancer surgery, lymphedema, or tissue trauma.
eng
GROWTH-FACTOR-C
PHENOTYPIC HETEROGENEITY
TRANSGENIC MICE
LYMPHANGIOGENESIS
PI3K
ANGIOGENESIS
ORIGIN
VASCULATURE
MANTEINANCE
PROGENITORS
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.
journal article
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