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oai:repisalud.isciii.es:20.500.12105/102912024-11-29T13:58:29Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Stanczuk, Lukas author Martinez-Corral, Ines author Ulvmar, Maria H author Zhang, Yang author Laviña, Bàrbara author Fruttiger, Marcus author Adams, Ralf H author Saur, Dieter author Betsholtz, Christer author Alitalo, Kari author Graupera, Mariona author Mäkinen, Taija author 2015-03-17 Pathological lymphatic diseases mostly affect vessels in specific tissues, yet little is known about organ-specific regulation of the lymphatic vasculature. Here, we show that the vascular endothelial growth factor receptor 3 (VEGFR-3)/p110α PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature. Using genetic lineage tracing, we demonstrate that part of the mesenteric lymphatic vasculature develops from cKit lineage cells of hemogenic endothelial origin through a process we define as lymphvasculogenesis. This is contrary to the current dogma that all mammalian lymphatic vessels form by sprouting from veins. Our results reveal vascular-bed-specific differences in the origin and mechanisms of vessel formation, which may critically underlie organ-specific manifestation of lymphatic dysfunction in disease. The progenitor cells identified in this study may be exploited to restore lymphatic function following cancer surgery, lymphedema, or tissue trauma. Cell Rep .2015 ;10(10):1708-1721 10.1016/j.celrep.2015.02.026 2211-1247 Cell reports 25772358 http://hdl.handle.net/20.500.12105/10291 GROWTH-FACTOR-C PHENOTYPIC HETEROGENEITY TRANSGENIC MICE LYMPHANGIOGENESIS PI3K ANGIOGENESIS ORIGIN VASCULATURE MANTEINANCE PROGENITORS cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.