2026-06-14T03:44:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/102662025-04-04T10:48:43Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959col_20.500.12105_16962col_20.500.12105_16964col_20.500.12105_16968col_20.500.12105_16970col_20.500.12105_16981col_20.500.12105_16983col_20.500.12105_16988
Repisalud
author
Perez-Gomez, Beatriz
author
Michel, Angelika
author
Romero, Beatriz
author
Pawlita, Michael
author
Fernández-Villa, Tania
author
Moreno, Victor
author
Martín, Vicente
author
Willhauck-Fleckenstein, Martina
author
Castilla Catalán, Jesús
author
Fernández-Tardón, Guillermo
author
Dierssen-Sotos, Trinidad
author
Santibáñez, Miguel
author
Peiró, Rosana
author
Jimenez-Moleon, Jose J.
author
Navarro, Carmen
author
Castaño-Vinyals, Gemma
author
Kogevinas, Manolis
author
de Sanjose, Silvia
author
Del Campo, Rosa
author
Waterboer, Tim
author
Lope Carvajal, Virginia
author
Lopez-Abente, Gonzalo
author
Pollan-Santamaria, Marina
author
Aragones, Nuria
author
Fernandez de Larrea-Baz, Nerea
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Marqués de Valdecilla
funder
Government of Catalonia (España)
funder
Junta de Castilla y León (España)
funder
Generalitat Valenciana (España)
2020-06-04T08:35:06Z
2020-06-04T08:35:06Z
2017
Cancer Epidemiol . 2017 Oct;50(Pt A):76-84.
10.1016/j.canep.2017.08.002
1877-783X
Cancer epidemiology
28888185
http://hdl.handle.net/20.500.12105/10266
Background: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. Methods: Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology. Infection was defined as seropositivity against≥4 proteins. Relation of serological results to non-cardia and cardia gastric cancer was assessed using multivariable mixed logistic regression and principal components analysis. Results: Seroprevalence was 88% among 2071 controls, 95% among 202 non-cardia gastric cancer cases (OR=1.9 (95% CI: 1.0-3.6)) and 85% among 62 cardia cancer cases (OR=0.5 (95% CI: 0.3-1.1)). In infected subjects, seropositivity for UreA, HP231, NapA and Cagδ was associated with lower non-cardia gastric cancer risk, while seropositivity for CagA and VacA was associated with higher risk. Seropositivity for CagA and seronegativity for Cagδ maintained the association after additional adjustment by serostatus of significant proteins. We identified two antibody reactivity patterns: the "virulent-pattern", related to a threefold higher risk of non-cardia gastric cancer and the "non-virulent pattern", related to a 60% decreased risk (4th vs. first quartile). Conclusions: In our population, people seropositive for H. pylori were characterized by two patterns of antibody reactivity against H. pylori proteins: 1) Combined high seroreactivity against several proteins, associated with a lower non-cardia gastric cancer risk, and 2) High seroreactivity against CagA and VacA, associated with an increased risk.
eng
Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study.
research article
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HelicobacterPyloriSerologicalBiomarkers_2017.pdf.txt