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00925njm 22002777a 4500 dc Perez-Gomez, Beatriz author Michel, Angelika author Romero, Beatriz author Pawlita, Michael author Fernández-Villa, Tania author Moreno, Victor author Martín, Vicente author Willhauck-Fleckenstein, Martina author Castilla Catalán, Jesús author Fernández-Tardón, Guillermo author Dierssen-Sotos, Trinidad author Santibáñez, Miguel author Peiró, Rosana author Jimenez-Moleon, Jose J. author Navarro, Carmen author Castaño-Vinyals, Gemma author Kogevinas, Manolis author de Sanjose, Silvia author Del Campo, Rosa author Waterboer, Tim author Lope Carvajal, Virginia author Lopez-Abente, Gonzalo author Pollan-Santamaria, Marina author Aragones, Nuria author Fernandez de Larrea-Baz, Nerea author 2017 Background: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. Methods: Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology. Infection was defined as seropositivity against≥4 proteins. Relation of serological results to non-cardia and cardia gastric cancer was assessed using multivariable mixed logistic regression and principal components analysis. Results: Seroprevalence was 88% among 2071 controls, 95% among 202 non-cardia gastric cancer cases (OR=1.9 (95% CI: 1.0-3.6)) and 85% among 62 cardia cancer cases (OR=0.5 (95% CI: 0.3-1.1)). In infected subjects, seropositivity for UreA, HP231, NapA and Cagδ was associated with lower non-cardia gastric cancer risk, while seropositivity for CagA and VacA was associated with higher risk. Seropositivity for CagA and seronegativity for Cagδ maintained the association after additional adjustment by serostatus of significant proteins. We identified two antibody reactivity patterns: the "virulent-pattern", related to a threefold higher risk of non-cardia gastric cancer and the "non-virulent pattern", related to a 60% decreased risk (4th vs. first quartile). Conclusions: In our population, people seropositive for H. pylori were characterized by two patterns of antibody reactivity against H. pylori proteins: 1) Combined high seroreactivity against several proteins, associated with a lower non-cardia gastric cancer risk, and 2) High seroreactivity against CagA and VacA, associated with an increased risk. Cancer Epidemiol . 2017 Oct;50(Pt A):76-84. 10.1016/j.canep.2017.08.002 1877-783X Cancer epidemiology 28888185 http://hdl.handle.net/20.500.12105/10266 Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study.