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oai:repisalud.isciii.es:20.500.12105/102352025-04-24T17:02:46Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16984

00925njm 22002777a 4500 dc Domingo-Relloso, Arce author Grau-Perez, Maria author Galan-Chilet, Inmaculada author Garrido-Martinez, Maria J author Tormos, Carmen author Navas-Acien, Ana author Gomez-Ariza, Jose L author Monzo-Beltran, Lidia author Saez-Tormo, Guillermo author García-Barrera, Tamara author Dueñas Laita, Antonio author Briongos-Figuero, Laisa author Martin-Escudero, Juan Carlos author Chaves, F Javier author Redon, Josep author Tellez-Plaza, Maria author 2019 Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03-1.27) for Mo, 1.17 (1.05-1.31) for Ba, 1.23 (1.04-1.46) for Cr and 1.18 (1.00-1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03-1.24) for Zn and 1.12 (1.02-1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA. Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation. Environ Int . 2019 Feb;123:171-180. 10.1016/j.envint.2018.11.055 1873-6750 0160-4120 Environment international 30529889 http://hdl.handle.net/20.500.12105/10235 Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study.