2026-06-14T03:45:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/101572024-11-28T16:06:44Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938col_20.500.12105_16984
Repisalud
author
Navarro, David
author
Fernández-Ruiz, Mario
author
Aguado, José María
author
Sandonís, Virginia
author
Perez-Romero, Pilar
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
funder
RETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España)
2020-05-18T10:18:04Z
2020-05-18T10:18:04Z
2019
Rev Med Virol. 2019 Jan;29(1):e2017.
10.1002/rmv.2017
1099-1654
1052-9276
Reviews in medical virology
30358016
http://hdl.handle.net/20.500.12105/10157
Knowledge of donor and recipient (D/R) cytomegalovirus (CMV) serostatus is critical for risk stratification of CMV infection and disease in transplant recipients, particularly in the solid organ transplantation (SOT) setting. Despite its broad availability and the success of it use, the risk stratification based on the D/R serostatus is not free of limitations since there are a nondepreciable number of patients that are not accurately categorized by this approach. In fact, up to 20% of seropositive SOT recipients, classically considered at intermediate risk, develop episodes of CMV infection and disease after transplantation. Here, we provide an overview of additional donor and recipient factors that may have utility in identifying patients at risk for post-transplant CMV infection. Specifically, we summarize our current understanding regarding the potential use of use CMV-specific T-cell-mediated immunity, neutralizing antibodies and host genetics that may influence the risk of CMV infection and disease. We provide an overview of the benefits and limitations associated with using these immunological factors in risk stratification and propose specific variables that could be analyzed at the pretransplant evaluation to improve the identification of patients with increased individual susceptibility.
eng
CMV-specific immune response
cytomegalovirus infection
serology
Going beyond serology for stratifying the risk of CMV infection in transplant recipients
journal article
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GoingBeyondSerologyFor_2018.pdf
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GoingBeyondSerologyFor_2019.pdf.txt
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GoingBeyondSerologyFor_2018.pdf.txt