2026-06-14T05:05:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/101552024-09-27T17:10:35Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609
Repisalud
author
Seppälä, Elina Marjukka
author
Lopez-Perea, Noemi
author
Torres-de Mier, Maria de Viarce
author
Echevarria, Juan Emilio
author
Fernandez-Garcia, Aurora
author
Masa-Calles, Josefa
funder
Instituto de Salud Carlos III
2020-05-18T10:10:38Z
2020-05-18T10:10:38Z
2019
Vaccine. 2019 Jan 3;37(1):169-175.
10.1016/j.vaccine.2018.11.017
1873-2518
0264-410X
Vaccine
30454948
http://hdl.handle.net/20.500.12105/10155
With a highly immunized population, rubella infection in Spain is so low that the WHO has declared the elimination of rubella. Rubella in pregnant women is also very rare. The objective of this study is to describe the last cases of congenital rubella syndrome reported and recommend actions to maintain the status of the disease as eliminated. The CRS cases reported to the Spanish National Epidemiological Surveillance Network between 1997 and 2016 were studied, and the epidemiological, clinical, diagnostic and maternal characteristics of newborns with CRS described. The incidence of CRS was calculated using Birth Statistics from the Spanish National Statistics Agency (INE). Twenty-three cases of CRS were reported, 70% of which were associated with rubella outbreaks. The most common clinical conditions were heart disease (52.2%), deafness (39.1%) and cataracts (30.4%); 91.3% of cases were confirmed by laboratory testing. 70.0% were born from a non-vaccinated foreign mother, resident in Spain (cumulative rate incidence (CR): 1.1/100,000 births), with mothers coming from Africa (36.0%), Latin America (29.0%), Eastern Europe (21.0%) and Asia (14.0%). Six were born to Spanish mothers (CR: 0.08/ 100,000 births), the last of which were in 2005. The majority of CRS cases were born to unvaccinated immigrant women infected in Spain during rubella outbreaks. Universal vaccination in childhood is the most efficient strategy to prevent rubella. The limited circulation of the virus will, however, quickly lead to a loss of awareness about rubella among clinicians and epidemiologists. It is necessary to maintain protocols capable of identifying signs consistent with rubella in pregnant women and signs suggestive of congenital rubella in newborns.
eng
Congenital abnormalities
Congenital rubella syndrome
Disease prevention
Emigration and immigration
Epidemiological surveillance
Genetic testing
Rubella
Rubella vaccine
Spain
Last cases of rubella and congenital rubella syndrome in Spain, 1997-2016: The success of a vaccination program
research article
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LastCasesOfRubella_2019.pdf
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https://repisalud.isciii.es/bitstreams/34dc9318-c07c-43e1-bf57-3354b983e361/download
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LastCasesOfRubella_2019.pdf.txt