2026-04-28T21:35:04Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/100872024-11-29T17:06:41Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud author Papaspyridonos, Marianna author Matei, Irina author Huang, Yujie author do Rosario Andre, Maria author Brazier-Mitouart, Helene author Waite, Janelle C author Chan, April S author Kalter, Julie author Ramos, Ilyssa author Wu, Qi author Williams, Caitlin author Wolchok, Jedd D author Chapman, Paul B author Peinado Selgas, Hector author Anandasabapathy, Niroshana author Ocean, Allyson J author Kaplan, Rosandra N author Greenfield, Jeffrey P author Bromberg, Jacqueline author Skokos, Dimitris author Lyden, David funder UK-US Fulbright Commission funder Garrett B. Smith Foundation funder Children s Cancer and Blood Foundation funder Hartwell Foundation funder Manning Foundation for Democratic Education funder Pediatric Oncology Experimental Therapeutics Investigator's Consortium funder Stavros Niarchos Foundation funder Champalimaud Foundation funder Nancy C. and Daniel P. Paduano Foundation funder Mary Kay Foundation funder Malcolm Hewitt Wiener Foundation funder National Foundation for Cancer Research (Estados Unidos) funder Susan G. Komen Breast Cancer Foundation funder Luso-American Development Foundation funder American Portuguese Biomedical Research Fund funder Fundação para a Ciência e Tecnologia (Portugal) funder Beth Tortolani Foundation funder Theodore A Rapp Foundation 2020-05-12T16:03:27Z 2020-05-12T16:03:27Z 2015-04-29 Nat Commun. 2015 Apr 29;6:6840. 2041-1723 http://hdl.handle.net/20.500.12105/10087 25924227 10.1038/ncomms7840 2041-1723 Nature communications A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive 'macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1 (Id1), in response to tumour-derived factors, such as TGFβ, is responsible for the switch from dendritic cell (DC) differentiation to myeloid-derived suppressor cell expansion during tumour progression. Genetic inactivation of Id1 largely corrects the myeloid imbalance, whereas Id1 overexpression in the absence of tumour-derived factors re-creates it. Id1 overexpression leads to systemic immunosuppression by downregulation of key molecules involved in DC differentiation and suppression of CD8 T-cell proliferation, thus promoting primary tumour growth and metastatic progression. Furthermore, advanced melanoma patients have increased plasma TGFβ levels and express higher levels of ID1 in myeloid peripheral blood cells. This study reveals a critical role for Id1 in suppressing the anti-tumour immune response during tumour progression and metastasis. eng Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation journal article 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 URL https://repisalud.isciii.es/bitstreams/31692ce5-cf3d-4695-8819-228018634633/download File MD5 48e4061ea17c6965c2b1cc3c4c92c244 1684974 application/pdf Id1suppressesanti-tumourimmune_2015.pdf URL https://repisalud.isciii.es/bitstreams/c2a43695-d9ad-4bce-a29f-350af2082e6b/download File MD5 3e0b85692b8fa0d13fcaef229e6e9233 2375653 application/pdf 41467_2015_BFncomms7840_MOESM245_ESM-2015.pdf URL https://repisalud.isciii.es/bitstreams/8487f4a2-ed7e-4a57-ad2d-e362e7ffd0a1/download File MD5 e6f6c9648779dec6994d842e9991218d 82165 text/plain Id1suppressesanti-tumourimmune_2015.pdf.txt URL https://repisalud.isciii.es/bitstreams/828b17b6-b142-4198-98af-6216d852aee7/download File MD5 ff72bedcabdb6223146db59d0d816584 8496 text/plain 41467_2015_BFncomms7840_MOESM245_ESM-2015.pdf.txt