2026-04-29T15:25:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/100012024-11-29T15:56:51Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Giraddi, Rajshekhar R
author
Shehata, Mona
author
Gallardo, Mercedes
author
Blasco, MA
author
Simons, Benjamin D
author
Stingl, John
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación AXA
funder
Botín Foundation
funder
Hutchison Whampoa Limited
funder
Cancer Research UK (Reino Unido)
funder
Comunidad de Madrid (España)
2020-05-08T15:12:15Z
2020-05-08T15:12:15Z
2015-10-29
Nat Commun. 2015;6:8487.
10.1038/ncomms9487
2041-1723
2041-1723
Nature communications
26511661
http://hdl.handle.net/20.500.12105/10001
The cycling properties of mammary stem and progenitor cells is not well understood. To determine the division properties of these cells, we administered synthetic nucleosides for varying periods of time to mice at different stages of postnatal development and monitored the rate of uptake of these nucleosides in the different mammary cell compartments. Here we show that most cell division in the adult virgin gland is restricted to the oestrogen receptor-expressing luminal cell lineage. Our data also demonstrate that the oestrogen receptor-expressing, milk and basal cell subpopulations have telomere lengths and cell division kinetics that are not compatible with these cells being hierarchically organized; instead, our data indicate that in the adult homeostatic gland, each cell type is largely maintained by its own restricted progenitors. We also observe that transplantable stem cells are largely quiescent during oestrus, but are cycling during dioestrus when progesterone levels are high.
eng
Stem and progenitor cell division kinetics during postnatal mouse mammary gland development
journal article
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Stemandprogenitorcelldivision_2015.pdf.txt
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