TY - JOUR AU - Fontecha-Barriuso, Miguel AU - Martín-Sánchez, Diego AU - Martinez-Moreno, Julio M AU - Carrasco, Susana AU - Ruiz-Andrés, Olga AU - Monsalve, Maria AU - Sanchez-Ramos, Cristina AU - Gómez, Manuel J AU - Ruiz-Ortega, Marta AU - Sánchez-Niño, Maria D AU - Cannata-Ortiz, Pablo AU - Cabello, Ramiro AU - Gonzalez-Enguita, Carmen AU - Ortiz, Alberto AU - Sanz, Ana B PY - 2019 DO - 10.1002/path.5282 UR - http://hdl.handle.net/20.500.12105/17396 AB - PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1α, PPARGC1A) regulates the expression of genes involved in energy homeostasis and mitochondrial biogenesis. Here we identify inactivation of the transcriptional regulator PGC-1α as... LA - eng PB - Wiley KW - Acute Kidney Injury KW - Animals KW - Cell Death KW - Cell Line KW - Cell Proliferation KW - Cytokines KW - Disease Models, Animal KW - Female KW - Folic Acid KW - Humans KW - Inflammation Mediators KW - Kidney KW - Lipocalin-2 KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Mitochondria KW - Nephritis, Interstitial KW - Organelle Biogenesis KW - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha KW - Severity of Illness Index KW - Signal Transduction TI - PGC-1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI. TY - journal article ER -