TY - JOUR AU - Kanellis, Dimitris C AU - Zisi, Asimina AU - Skrott, Zdenek AU - Lemmens, Bennie AU - Espinoza, Jaime A AU - Kosar, Martin AU - Björkman, Andrea AU - Li, Xuexin AU - Arampatzis, Stefanos AU - Bartkova, Jirina AU - Andújar-Sánchez, Miguel AU - Fernandez-Capetillo, Oscar AU - Mistrik, Martin AU - Lindström, Mikael S AU - Bartek, Jiri PY - 2023 DO - 10.1038/s41418-023-01167-4 UR - http://hdl.handle.net/20.500.12105/17252 AB - Drug repurposing is a versatile strategy to improve current therapies. Disulfiram has long been used in the treatment of alcohol dependency and multiple clinical trials to evaluate its clinical value in oncology are ongoing. We have recently reported... LA - eng PB - Nature Publishing Group KW - Disulfiram KW - Neoplasms KW - Animals KW - Humans KW - Cell Line, Tumor KW - Ribosomes KW - Tumor Suppressor Protein p53 KW - Zebrafish TI - Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET. TY - journal article ER -