TY  - JOUR
AU  - de Carcer Diez, Guillermo
AU  - Wachowicz, Paulina
AU  - Martinez-Martinez, Sara
AU  - Oller, Jorge
AU  - Mendez-Barbero, Nerea
AU  - Escobar, Beatriz
AU  - González-Loyola, Alejandra
AU  - Takaki, Tohru
AU  - El Bakkali, Aicha
AU  - Cámara, Juan A
AU  - Jimenez-Borreguero, Luis J.
AU  - Bustelo, Xosé R
AU  - Cañamero, Marta
AU  - Mulero, Francisca
AU  - de Los Ángeles Sevilla, María
AU  - Montero, María Jose
AU  - Redondo, Juan Miguel
AU  - Malumbres Martinez, Marcos
PY  - 2017
DO  - 10.1038/nm.4364
SN  - 1078-8956
UR  - http://hdl.handle.net/20.500.12105/9809
AB  - Polo-like kinase 1 (PLK1), an essential regulator of cell division, is currently undergoing clinical evaluation as a target for cancer therapy. We report an unexpected function of Plk1 in sustaining cardiovascular homeostasis. Plk1 haploinsufficiency...
LA  - eng
PB  - Nature Publishing Group
KW  - Angiotensin II
KW  - Animals
KW  - Aorta
KW  - Aortic Aneurysm
KW  - Aortic Rupture
KW  - Blood Pressure
KW  - Cell Cycle Proteins
KW  - Cell Proliferation
KW  - Fluorescent Antibody Technique
KW  - Gene Knockdown Techniques
KW  - Haploinsufficiency
KW  - Homeostasis
KW  - Hypotension
KW  - Immunoblotting
KW  - Mice
KW  - Microscopy, Electron, Transmission
KW  - Mitosis
KW  - Muscle, Smooth, Vascular
KW  - Myocytes, Smooth Muscle
KW  - Protein-Serine-Threonine Kinases
KW  - Proto-Oncogene Proteins
KW  - Real-Time Polymerase Chain Reaction
KW  - Vascular Stiffness
KW  - rho GTP-Binding Proteins
TI  - Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis
TY  - journal article
ER  -