TY - GEN AU - Fernandez-Valenzuela, Juan Jose AU - Sanchez-Varo, Raquel AU - Muñoz-Castro, Clara AU - De Castro, Vanessa AU - Sanchez-Mejias, Elisabeth AU - Navarro, Victoria AU - Jimenez, Sebastian AU - Nuñez-Diaz, Cristina AU - Gomez-Arboledas, Angela AU - Moreno-Gonzalez, Ines AU - Vizuete, Marisa AU - Davila, Jose Carlos AU - Vitorica, Javier AU - Gutierrez, Antonia PY - 2020 DO - 10.1038/s41598-020-71767-4 UR - http://hdl.handle.net/20.500.12105/18114 AB - In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation of hyperphosphorylated tau... LA - eng PB - Springer KW - Amyloid KW - Alzheimer disease KW - Axonal transport KW - Brain KW - Interneurons KW - Tauopathies KW - Amiloide KW - Enfermedad de Alzheimer KW - Transporte axonal KW - Encéfalo KW - Interneuronas KW - Tauopatías KW - Alzheimer Disease KW - Animals KW - Axonal Transport KW - Cognition Disorders KW - Epothilones KW - Female KW - Humans KW - Male KW - Mice KW - Mice, Transgenic KW - Microtubules KW - Neurons KW - Phenotype KW - Tauopathies KW - Tubulin Modulators KW - Disease Models, Animal TI - Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model TY - research article ER -